Etienne Sibille

Administrative Assistant: Mehrab Ali, Mehrab.ali@camh.ca

Research Synopsis

The goals of my research program are to investigate the cellular and molecular mechanisms underlying major depressive disorders (MDD), life-long maturation or aging of the brain, and their respective interactions and, to use this knowledge to develop strategies for novel therapeutic approaches. To reach these goals, we use large-scale genomic, molecular and biostatistical approaches to characterize the primary pathology in human postmortem brain samples. Furthermore, we use relevant genetic and environmental mouse models to investigate causal links between the identified pathologies (e.g. BDNF/GABA dysregulations) and mood regulatory mechanisms. Finally we test novel therapeutic strategies at the behavioral and molecular/cellular levels.