Ori Rotstein Lecture in Translational Research
The annual Ori Rotstein Lecture in Translational Research is an important event for the Institute of Medical Science - it is a time to celebrate the exceptional scientific contributions of our scientific community.
The Ori Rotstein Lecture in Translational Research was established in 2011 to mark Dr. Rotstein's 25-year engagement with the IMS. Dr. Rotstein is an IMS alumnus, former IMS Director (2000-2010) and long-standing faculty member. Dr. Ori Rotstein is now the Vice President of Research and Innovation at Unity Health Toronto. He is also a Professor and Associate Chair of the Department of Surgery at the University of Toronto. We are honoured to have him come back and host this Annual Lecture each year.
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Keynote Speaker:
Biological sex and disease mechanisms: Insights into obesity, drug reactions, and cardiovascular disease risk
Karen Reue, PhD, is Professor of Human Genetics in the David Geffen School of Medicine at UCLA and Director of the NIH Scientific Center of Research Excellence (SCORE) on Sex Differences in Cardiometabolic Health and Disease.
The Reue laboratory is interested in the identification of genes and pathways that are required for metabolic homeostasis. A current focus is the role of biological sex as a determinant of cardiometabolic disease. These studies use mouse models that parse the contributions of gonadal sex (ovaries vs. testes) and chromosomal sex (XX vs. XY chromosomes). A key finding has been the unexpected importance of X chromosome gene dosage in many cardiometabolic traits including adipose tissue function obesity, regulation of serum lipid levels, atherosclerosis, mitochondrial function, and statin drug adverse effects.
Planning Committee Members
- Faculty Co-Chairs: Drs. John Vincent and Dmitry Rozenberg
- Staff Lead: Sobiga Vyravanathan
- Student Co-Leads: Slaghaniya Neupane and Joanna Cunanan
- Creative Content: Melissa O’Neil, Anthaea-Grace Dennis, and Caroline Marr
- Panelist Communications: Nafia Mirza, Phuong Nguyen, Megana Thamilselvan
- Promotions and Marketing: Karem Abdul-Samad, Mandy Guo, Ingrid Campbell, and Anita Rajkumar
- MSC1010 Course Liaison: Paige McKinley