Vinod Chandran
Administrative Assistant: Anne MacKinnon, Anne.MacKinnon@uhnresearch.ca, 416-603-5800 ext. 2511
Research Synopsis
Dr. Chandran’s scientific expertise is in the genetic and molecular epidemiology of psoriatic disease (PsD; psoriasis and psoriatic arthritis [PsA]). This lifelong disease strikes patients in their youth, and is currently incurable, leading to progressive joint damage, functional limitation, poor mental health, reduced quality of life, and increased mortality. His translational research program focuses on understanding PsD pathobiology with particular emphasis on untargeted global discovery of novel biomarkers and drug targets using high throughput and augmented intelligence technologies.
His main goal is the improved and personalized management of PsD by:
- aiming at early diagnosis of PsA;
- identifying patients with psoriasis at high risk of developing PsA and developing interventions to intercept this transition;
- identifying subjects with PsA at high risk of developing arthritis mutilans; and
- developing drug or other interventions to treat the estimated 40% of PsA patients not responding to current therapy.
Dr. Chandran is currently looking for graduate trainees (PhD/MSc) for the following projects:
- Metabolomics of psoriatic disease in order to identify metabolomic markers for diagnosis, stratification, and treatment response.
- Integrated omics coupled with machine learning to develop a psoriatic disease data integration portal.