Professor
|
Full Member
Stephen Lye
Location
Mount Sinai Hospital
Research Interests
Reproductive & Development, Women’s Health, Children’s Health, Genetics, Epigenetics, Endocrine System
Research Themes
Other
Research Synopsis
The focus of our laboratory is to understand the mechanisms responsible for the onset of labour. We are investigating whether the change in the myometrium from a dormant state to the contractile state that occurs during labour is caused by the activation of genes. The lab has shown that both mechanical signals (due to stretching of the myometrium) and endocrine signals are required to activate a cassette of genes called "contractile-associated proteins" (e.g. CX-43 and oxytocin receptor) and initiate labour.