Patrick Lawler

Research Synopsis

I am a clinician scientist at the Peter Munk Cardiac Centre at University Health Network, where I attend in the cardiac intensive care unit, and an Assistant Professor of Medicine at the University of Toronto.

My research aims to develop personalized medicine approaches for the prevention and treatment of cardiovascular disease and critical illness. This work has a strong scientific focus on inflammation and metabolism, is at the intersection between cardiovascular disease and sepsis, and leverages molecular epidemiology/systems medicine approaches in epidemiology and clinical trials. I also have a focus on Bayesian adaptive/platform trials in critical care medicine, and serve on the International Trial Steering Committee of the REMAPCAP global adaptive platform trial (NCT02735707), on the Protocol Development/Leadership Committee for the NIH/NHLBI ACTIV-4 platform trial (NCT04505774), and as co-Principal Investigator of the ATTACC adaptive trial of anticoagulation in hospitalized patients with COVID-19 (NCT04372589) which completed enrollment of 1,204 patients at 62 hospitals in 4 countries. My research is funded by the Canadian Institutes of Health Research and the U.S. National Institutes of Health, among others.