Marc Jeschke

Research Synopsis

Dr. Marc G Jeschke is a Senior Scientist and the Director of the Ross Tilley Burn Center at Sunnybrook Health Science Center. He is a Professor in the Department of Surgery, Department of Immunology and the Institute of Medical Science. The focus of his work is translational research with the employment of basic and clinical research in burns. Within his laboratory he has two active groups, one is focusing on Skin stem cells and skin regeneration and the other is focusing on immune-metabolism aspects of burn. In the group of Stem cell and Skin Regeneration, the group employs different in vitro and in vivo approaches to enlighten the process of healing post injury. Using different sources of stem cells in the lab, they aim to create a skin substitute that can be used for burn patients. Finding new sources of stem cells and their combination together with an optimal approach to print the cells in a 3D format is the focus of the group. The Immunometabolism group is trying to identify agents that mediate profound metabolic alterations and understanding how these agents function in burn patients. In particular, the group is interested in addressing the role of the communication between the different metabolic organs (mainly liver and adipose tissue) and inflammatory cells in the installation of hypermetabolism and its complications.