Darius Bagli

Research Synopsis

Our lab group is currently focused on the epigenetics of benign (or not) urological disease. This interest grew out of long standing interest in cell-matrix interactions and mechanotransduction that underlie obstructive bladder disease. This pathology incites uncontrolled smooth muscle overgrowth and matrix deposition int he organ. The persistence of the disease despite relieving obstruction has led us to consider that an epigenetic mechanism may participating in a response to the altered matrix environment. This has led to additional projects in the epigenetics of bacterial-host interaction as well as environmental hormonal disruptors and genital maldevelopment, two additional major problems for uroloigical health and disease in humans.