Arndt Vogel

Research Synopsis

The Vogel laboratory, situated within the newly inaugurated Liver Labs at the Max Bell facility of the Toronto General Hospital Research Institute, is focused on liver cancer research—a pivotal area in the study of one of the most prevalent and aggressive tumor types worldwide. Our research program is multifaceted, delving into critical aspects of the disease, including tumor evolution, therapy options and strategies, as well as mechanisms of drug resistance.

Our interests span both wet and dry components of the research landscape. In the wet lab domain, we engage in comprehensive investigations utilizing murine models of liver cancer, patient-derived organoids (PDO), xenografts (PDx), molecular profiling, multiplex immunohistochemistry, and drug screening. Simultaneously, in the dry lab arena, we specialize in the analysis of RNA-seq data (both bulk and single cell), along with the scrutiny of large datasets. This encompasses data integration efforts and translational analysis of patients treated in investigator-initiated trials.