Andrea Knight

Administrative Assistant: Jeremae Jamorabon, jeremae.jamorabon@sickkids.ca

Research Synopsis

Dr. Knight’s clinical research program seeks to improve mental health and overall outcomes for paediatric patients with paediatric systemic lupus erythematosus (pSLE) and other rheumatologic disease. 

She is utilizing cognitive and psychiatric measures along with advanced neuroimaging techniques to examine the impact of pSLE on neurocognitive health and brain development, and to identify mechanisms of neuropsychiatric dysfunction in pSLE. Understanding the underlying mechanisms will enable development of approaches for early detection and targeted treatment of neuropsychiatric disorders in pSLE.

Dr. Knight’s work also focuses on psychiatric comorbidity for patients with pSLE and other rheumatologic disease. She is using administrative data, survey and mixed methods approaches to understand the effect of psychiatric comorbidity on outcomes, and to develop and test mental health interventions for these patients.