Albert H.C. Wong

Research Synopsis

Delusional belief formation in schizophrenia
There are complementary human and mouse model components to this project, which will test the overall hypothesis that delusions arise from distorted time perception. In this model, aberrant time perception generates errors in the ordering or sequencing of events, which forms the kernel of delusional beliefs about mind reading, lack of internal agency, and paranoia in general. Errors in event timing arise from impaired synchrony of the baseline electrical oscillations across the brain, which is due to abnormal development of GABA interneurons in the cerebral cortex in schizophrenia. 

Dynamic molecular biomarkers of suicidal ideation
Embedded in the larger suicide prevention study in the CAMH ED, this project will screen mRNA, protein and DNA methylation in patients for changes that are associated with suicidal ideation and behaviour. Samples taken from the same subject at different time points, in which there are differences in the severity of suicidal thinking or behaviour will undergo these broad analyses in an attempt to identify novel molecular targets or pathways involved in the pathophysiology of suicide.