Walter Kahr

Research Synopsis

Dr. Kahr's research is aimed at understanding the development and function of platelets, tiny blood cells that initiate and co-ordinate clotting at wounds. Platelets do this by adhering, aggregating and secreting a wide assortment of molecules, which helps normal clotting and can also contribute to thrombi that cause heart attacks and strokes. Many of his insights into the mechanisms of platelet development and function have come from studies of patients with inherited disorders. His particular interest is alpha granules, which platelets use to transport and secrete several hundred different proteins. His team has identified several proteins and cellular pathways involved in the development of alpha granules in the cells that produce platelets, the bone marrow megakaryocytes.