Sun-Ho Lee

Administrative Assistant: Tharsika.Suntharalingam@sinaihealth.ca; Clinic Tel: +1-416-586-4800 x 2437

Research Synopsis:

Dr. Lee was appointed Assistant Professor and Clinician Scientist at the Inflammatory Bowel Disease Centre at Mount Sinai Hospital in 2023. He previously completed his GI Fellowship at Asan Medical Center, Seoul, Korea. He further trained as an Advanced Inflammatory Bowel Disease Fellow (2018-2022) at Mount Sinai Hospital in Toronto. He also completed his Ph.D. degree at the Institute of Medical Science at the University of Toronto in May 2022.

Dr. Lee's research focuses on IBD translational research. He has been leading research projects as part of the CCC-GEM Project Research Team, where he contributed in understanding the pre-clinical phase of Crohn's disease. Using his biostatistics and bioinformatics skill set, he has explored the interaction of host genetics, gut microbiome, anti-microbial immune response, and the gut barrier function and how it relates to future development of IBD.

He is interested in exploring the role of novel -omics in IBD precision medicine (e.g., microbiome, metagenomics, metabolomics, PhIP-Seq, immunophenotyping, polygenic risk scores), using advanced bioinformatics, causal mediation, and machine learning models. He aims to determine the key triggering microbial, metabolomic, and host immune response-related factors that contribute to IBD pathogenesis. He also aims to develop integrative machine-learning models to risk stratify individuals at higher or lower risk of developing IBD, disease complications and poor treatment responses.