Marianne Koritzinsky

Research Synopsis

Research in Dr. Koritzinsky's laboratory is focused on vulnerabilities in cancer that emerge as a consequence of the tumor microenvironment. Tumor hypoxia confers poor patient prognosis due to resistance to radiation and chemotherapy, and stimulation of a more aggressive phenotype. The aim of Dr. Koritzinsky’s research program is to increase our understanding of molecular and cellular responses to hypoxia, with the ultimate goal of targeting these responses to improve cancer treatment efficacy, mitigate cancer aggressiveness and improve patient outcomes. Research is focused on determining how cancer cells regulate metabolism, redox homeostasis and secretion capacity.