Professor
|
Full Member
Katherine Siminovitch
Location
Mount Sinai Hospital
Research Interests
Autoimmune Disease, Immunology, Genetics, Animal Models
Research Themes
Infection, Immunology
Research Synopsis
Dr. Siminovitch's research program is directed at identifying the genetic and cellular mechanisms modulating expression of the immune response and development of immunologic diseases. The lab is now focused on defining the molecular events conferring risk for and modulating outcome of chronic autoimmune inflammatory diseases and in particular rheumatoid arthritis, primary biliary cirrhosis and Wegener's granulomatosis. To this end, the lab capitalizes on its access to unique mouse models and patient cohorts to delineate the gene variants conferring risk for these diseases and the effector pathways linking such variants to disease.