Katalin Szaszi

Research Synopsis

Dr. Szaszi is a cell biologist whose research focuses on epithelial biology and pathophysiology. Her main area of interest is the role and regulation of Rho family proteins and tight junctions by inflammatory stimuli. Her lab has shown that the Rho exchange factor GEF-H1 is a key mediator of Tumor Necrosis factor (TNF)-induced Rac and RhoA activation and demonstrated the role of phosphorylation in the differential regulation of this protein towards Rac and RhoA. Recently, they have found that TNF treatment induces a biphasic effect on the tight junction protein claudin-2 with and initial increase and a late decrease, and described the underlying mechanisms. Her lab explores the role of these proteins in animal models of kidney diseases. Dr. Szaszi has more than 50 peer-reviewed well cited publications.