John Floras

Administrative Assistant: Anette Pereira, annette.pereira@sinaihealth.ca

Research Keywords: Neural and endothelial mechanisms of cardiovascular regulation in humans, heart failure, hypertension, cardiopulmonary interactions, sleep apnea, exercise, chemoreceptor reflexes

Methods Keywords: Human subjects, sympathetic nerve recordings, cardiac Doppler ultrasound, heart rate and blood pressure variability, plethysmography, ambulatory blood pressure recording

Research Synopsis

Dr. Floras’ current research focuses on the elucidation and modulation of paradoxical reflexes that increase norepinephrine release from sympathetic nerve endings in heart failure; brain regions altered in heart failure and sleep apnea that amplify such reflex pathways; the impact of kidney failure and modes of dialysis for its treatment on hypertension and coronary artery blood flow, and the effect of treating obstructive sleep apnea or central sleep apnea, when present in heart failure, with adaptive servo ventilation on cardiovascular mortality and hospitalization.