Darrell Tan

Research Synopsis

Darrell H. S. Tan is an infectious diseases physician and Clinician-Scientist at St. Michael’s Hospital, where he leads the Options Collaboratory in HIV/STI Treatment and Prevention Science (www.optionslab.ca).  He is also an Associate Professor in the Department of Medicine at the University of Toronto, with cross-appointments at the Institute of Health Policy, Management and Evaluation and in the Institute of Medical Science.  His research focuses on clinical trials and implementation science in the areas of HIV prevention and treatment, sexually transmitted infections (STIs), and mpox.   Dr. Tan holds a Tier 2 Canada Research Chair in HIV Prevention and STIs, is Co-Lead of the HIV Prevention Core of the CIHR Canadian HIV Trials Network and is a member of the Governing Council of the International AIDS Society.  

A major focus of his work is on the implementation of HIV pre- and post-exposure prophylaxis (PrEP and PEP), and he has led the development of Canadian PrEP and PEP guidelines.  Recent and ongoing projects include: a randomized trial of text-messaging support vs standard care for people receiving HIV PEP, a multi-component implementation science study on HIV PrEP for sexual minority men, an observational cohort study of people with mpox infection, and a pilot randomized trial of valacyclovir as PEP and PrEP for preventing herpes simplex virus type 2 infection.