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Hypermutation in Human Cancer: PhD student Brittany Campbell takes the lead in ‘Cell’

By Michelle Rosen

NOVEMBER 7, 2017

Congratulations to Institute of Medical Science, PhD Candidate Brittany Campbell who is being recognized for her work as first author on a groundbreaking paper published in Cell on October 19, 2017.  The paper, Comprehensive Analysis of Hypermutation in Human Cancer finds that tumors with hypermutation carry a signature that can tell us things about the life history and evolution of the cancer, including the underlying driving biological processes and prior therapy. They also can be used to determine eligibility for novel therapies, including immune-based therapies and identifying patients with a cancer predisposing syndrome.

Cell:

Comprehensive Analysis of Hypermutation in Human Cancer

SickKids News:

SickKids scientists create new way to classify cancers based on unique hypermutant footprint